The Human Microbiome Project

The Human Microbiome Project Microorganisms are important for animal and plant life, their presence in the surroundings is essential for survival of all life forms. This importance can be proved by the large number of prokaryotes in human body, mainly bacteria, it was found that there are ten time more bacteria than human cells. Normal flora describe the microbes that colonize human body, during birth and after, and remain for life. Microbes of normal flora are found in many body sites, such as moist skin, gastrointestinal tract, mouth, respiratory tract, urinary tract, and vagina, but other important human organs, such as lungs, brain, and heart are free from microbial flora. Number of microorganisms living in skin is small compared to other sites, because skin medium is dry, and contain dead cells, with slight low pH. The human respiratory tract, mainly nose, is colonized by Staphylococcus aureus , which is main cause of surgical wound infection. The mouth contains biofilms of Streptococcus mutans, which are p resent as plaque on teeth surface. Similar to the skin, and unlike small intestine, not many microbes live in the stomach, because of the gastric acid, Helicobacter pylori is an example of stomach bacteria. Human microbial flora are important to the human, staphylococci and propionibacteria, release fatty acids to prevent growth of skin fungi, bacteria in respiratory tract can cause infections when epithelium of respiratory tract get damage. Vaginal flora, mainly lactobacillus protect host, as women with low lactobacillus levels taking antibiotics to treat infection develop other infections. Human flora also benefit the host, they colonize body sites, making it difficult for external microbes to colonize and infect, they also help in vitamin production, and cause small antibody release , which help in immunity. Oral microflora produce substances as fatty acid, peroxides to protect from external microbes, and also cause disease such as gingivitis, and dental plaque. Normal flora spread from site to another can cause deadly infections, as from wound. Bacteroides of the gastrointestinal tract produced substances that are carcinogens, and can cause cancer for colon. Human Microbiome Project (HMP) Researchers found, usually that everybody carries huge number of pathogens, and microorganisms as possible to cause diseases. While most of these microorganisms coexist with the host body (healthy individuals) and remnant of the human microbiome without any diseas and living with each other in the human body, which are play important vital role in human health. Researchers sampled of healthy volunteers in USA had included total samples was from 15 body sites in men, while in women was 18 body sites, from each volunteer was collected three samples at different body sites. Collect the samples from a total of 18 body sites, in 5 major body areas, in males were sampled from the skin, mouth (oral cavity), nose, two sites behind each ear and each area inner elbow, lower part of gastrointestinal tract(stool), and tinal tract regions. On the other hand, in females additionally sampled from three vaginal sites, as following: nine sites in the oral cavity with saliva, four sites on the skin, three sites in the vagina, a pooled sample of the anterior nares (airway), and one sample of stool. In late 2007 with funding from the National Institutes of Health (NIH) roadmap for biomedical research community, represent important issues that affect human health in general, launched the Human Microbiome Project (HMP), which focuses on describing the different types of microbial which are associated with human health and disease. Human Microbiome Project is to study the microbes which are living in and on the human body and included catalogue the genetic identity and characterize of many organisms such as bacteria, viruses and live in intimate contact with human body. The Human Microbiome Project is became able to uncover microbes and the National Institutes of Health launched the results of the five-year project. Also, has been developed metagenomic protocols through generation a population-scale framework to produce metagenomic data and large group of quality-controlled resources, during standardized methods. Have been isolated around 800 reference strains from human body sequences. Although, these data are biggest resource to develop of current and future studies and represent a diversity of the human microbiome. Since launch HMP in late 2007, HMP has received $153 million from Common Fund of National Institutes of Health (NIH) and $20 million an additional. The main goals of this project are: This project is to prove if there is a shared core microbiome between different groups of people and in and on the different sites of the human body, also to studying different medical conditions  and explain whether there are a correlations between changes in microbiome and disease. To take benefit of recent technologies by studying samples from different sites of the human body to characterize the human microbiome, to provide new technological approaches from a standardized data resources, and HMP is working to manipulation of the human microbiome to improve human health. In addition, Human Microbiome Project provided contribution important to develop new fields in the technological and bioinformatic tools, through five year effort. The first stage of this initiative was included the sequencing of many hundreds of microbial reference genomes which isolated from human body sites. This information acquired from the reference genomes can help to functional annotation and classification of 16S rRNA from microbiome samples. In human body microbial partners carry out a several of metabolic reactions which are important for human health, still are not encoded in the human genome. Although, the large number of microbial kinds existent in the body did not isolated, because, the inability in the lab to reproduce suitable growth conditions for microbial. Therefore there are huge number of microbial are still undetectable. It is important the study of microbial communities directly from their natural habitats by benefit of advances in sequencing technology. The HMP is working to characterize the human microbiome communities by using different complementary analyses included: 16S ribosomal RNA (rRNA), metagenomic sequencing and whole-genome shotgun (WGS), which focused on examination of the intestine microbiome through the use of WGS data. The metagenome is includes the collective genomes of the human microbial flora. Generating a huge amounts of data from the sequencing and analyzes of reference genomes about the complexity of the human microbiome which are isolate from different sites of the human body and providing more information about human health and disease. 16S and wgs sequencing occurred in a four stages are: containing of a mock data pilot stage, a clinical pilot stage, in July 2010 stage 1 completed and clinical stage 2 currently in progress. Has been funded Fifteen demonstration projects to explain the nature of relationship between the microbiome, health and disease. It is known that the human microbiome is consists of the genes and genomes of the microbiota which resident throughout human body. The Human Microbiome Project resources, includes the following: 600 microbial reference genomes, 700 metagenomes, 60 million predicted genes, and 70 million 16S sequences from healthy adult microbiomes. The human microbiome including of microbial genes, genomes, and gene products of the microbiota which interact with the human body host to prime immunity and in same time to maintain host health. Also, the microbiome is contribute to maintenance and development of the immune system. The HMP is surveying the microbiomes pass the bodies of a group of healthy adults to produce data groups of microbiomes, to developing of reference strains by a classification of microbial genome sequences, and evaluating the properties of microbiomes which associated with specific skin diseases, gastrointestinal tract, and urogenital. Recently, has been developed three programs in technology are: the ethical, legal implications, and computational tools to support this field (microbiome research). In addition, there are four projects listed under the HMP program, depending on the four data sets produced, including: data sets produced in individual demonstration project activities; targeted 16S ribosomal RNA gene sequences; reference strain microbial genome sequences; and whole-genome shotgun metagenomic sequences. Whereas, the second major resource of the HMP is include five major areas of the human body (healthy adults) are: skin, mouth, nose, gastrointestinal tract, and vagina. In spite of, in the early years at birth, the generating of the microbiome, occurs through interact between the diet, maturing immune system and microbial communities. (Koenig et al., 2011) (Dominguez-Bello et al., 2010) . Difficult to understand what is happening through interactions between the microbiome function, early microbiome events and changes during the stages of life, such as using antibiotics possible to be predisposing factor to allergies later in life (Bisgaard et al., 2011). Also, because microbiome disorders might occur in childhood can lead to many diseases such as asthma, and type 1 diabetes. Each site of the body contains a unique microbiome important to maintain for the host health, for example the gastrointestinal microbiome which directly interacts with the immune system of the host (Round and Mazmanian, 2009). In addition to many functions as energy supply for host cells and digestion of food. The microbiome acquired be through anew each generation but it is not inherited. Currently, a lot of international efforts focused on enhance the understanding of the complexity of the human microbiome and determining the multiple pathological mechanisms for explore in human health and disease. The International Human Microbiome Consortium (IMHC) is open to support most research programs of human microbiome, the aim of the IMHC is the collection of information and understanding how the human microbiome is working to maintenance of human health and occurrence of diseases, for the purpose of illustrate that the relationship between the human microbiome, human health and disease. Also, other goals are in- depth study in the complexity of the microbiome in health and disease in general, make a full analysis of the human microbiome about human health and/or disease, creating the novel diagnostic tools of the disease and development of new methods to prevent and treat diseases and therapeutic interventions. In addition, that future researches aims to detect and to look for the important role of metagenomic analyses to defining DNA sequences and help to detected human infections because of the complexity of the human microbiome.

Alexander III Essay -- essays research papers

Alexander III According to Plutarch, Alexander was born on the sixth of Hecatombaeon (July) in the year 356 B.C. He was the son of Philip, king of Macedon,and Olympias. Supposedly on the day he was born the temple of Artemis burnt down, signifying his future glory. Not much is known of the youth of Alexander. It is known that he was taught by Aristotle and had a love of the Greek epic poems. One famous story from his youth is told in Plutarch's life of Alexander. Philonius the Thessalian brought the horse Bucephalus to Philip offering to sell him for thirteen talents. Philip and his attendants brought the horse to a field to try him. When they got there none of Philip's attendants could even mount him. They were leading the horse away when young Alexander asked for a chance to ride him. A wager was made that if Alexander could not ride the horse he would pay the price for the horse. After the wager was made Alexander took the horse and pointed him in the direction of the sun. He had noticed that the horse was afraid of his own shadow. He then mounted the horse and began to ride, to the amazement of all who watched. When he got off the horse Philip kissed his son. Plutarch also tells of Alexander entertaining Persian ambassadors while his father was not present. When Alexander was 16 Philip left him in charge of Macedon when Philip went to fight the Byzantines. When Alexander was 20 his father was murdered at the theatre. Some say that Alexander had a part in the plot to assasinate his father but almost all agree that his mother Olympias was a key figure in the death of Philip. Whatever the case may be Alexander took the throne in 336 B.C. Alexander is known for his conquest into Persia. When there, he performed hellenization. Hellenization is the attempt to become "Greek." Alexander helped this process along in the lands that he conquered. Another of the things that Alexander did was he set up cities where ever he went. Garrisons were left in these cities. These colonists would become the ruling class. They would then impose laws or rules to promote hellenization. Also in these cities gymnasiums were set up. Gymnasiums were the center of most Greek cities. What better way to make Persian cities sim... ...at the theatre, Hephaestion ate a fowl for dinner, and drank a large draught of wine. He quickly fell ill and shortly thereafter, died. Alexander was so completely upset that he ordered the tails and manes of all the horses be cut to show respect. He then crucified the doctor, Glaucus. Alexander III had another party in Susa. Susa was the adminsrative capital of the Persian empire. Alexander first went to Susa shortly after the Battle of Gaugamela. There he took control of the money, totalling 50,000 talents($60 million) as well as the rest of the royal property. Alexander was again in Susa in 324 B.C. There he performed a mass marriage. Between eighty and a hundred Macedonian officials took one Persian women each, including Hephaestion and Ptolemy. Alexander himself took two new brides. The wedding was done in traditional Persian style. The bridegroom would sit down in chairs, after a toss the brides came in, took them by the hand, and kissed them. Every guest that sat down for the banquet(roughly 30,000) had a gold cup before them. The celebration went on for no less than 5 days. There was also a big parade in the park.

History of Chines Opera and its effect on World Music Essay

The search for creativity and originality is deeply rooted in human nature such that it represents an inescapable and defining requirement of the human being. Since in man’s creative restlessness beats and pulsates what is most deeply human- the search for knowledge. A major issue in the history of china is its opera Extolling the great the importance of opera, it could be said that the Chinese by nature desire opera. Thus, making opera their delight and links it with their quest for survival. Opera can therefore be said to be ontological to them or the existentialist parlance, it is part of their existentiality since man for them is condemned to creative works and performance. To Elucidate more on the History of Chinese opera and its effect on world music is why I considered the topic â€Å"An analytical exposition on the history of Chinese opera and its effect on world music† very pertinent as an effort in enriching our human culture and our existence. My goal in this study is not to probe into the nature of Chinese opera but, to evolve and analytical exposition on its history and how it has imparted an effect on world music. The Concept of Opera: An opera is a staged dramatic work that is entirely sung. However, there are many exceptions to this rule. There are operas in which the actors sing in between spoken dialogue, and others that are semi-staged. Some operas are constructed with action scenes called recitative. Personal commentary or scenes involving inner thoughts and emotions are called arias. An aria is a song in which a character may share his or her feelings with the audience and fellow characters. Occasionally this is done in an ensemble with two or more singers and then the aria becomes a duet, trio, quartet, etc. epending on the number of singers involved. Composers used recitative to advance the story while arias, duets, trios, and quartets often were comments on the action. In most modern opera, composers no longer use the structure of recitative and aria, but blend the two styles together to create a more realistic picture of continuous drama. Characters in opera are developed by the composer and given certain voices to best illustrate their personality and role. Opera is thought to be the single greatest art form because it combines many artistic disciplines into one. The Nature of Chinese Opera; a Historical Survey: Chinese traditional opera is a comprehensive performing art which combines singing, music, dialogue, acrobatics, martial arts, and pantomime. It represents the culmination and distillation of two thousand years of Chinese civilization. A traditional form of stage entertainment, weaving together elements of mime, dance, song, dialogue, swordplay, and acrobatics into one fluid continuous flow. Gestures, movements and expressions incorporated within each performer’s script come together to bring forth an impressive performance. In contrast to Western stage entertainment, which is subdivided into different categories such as opera, drama and sketches, Chinese opera has remained faithful to its original format over the centuries. By doing away with three-dimensional stage props and complicated backdrops found in Western opera, Chinese opera conveys the idea of time and space to the audience through the acting of performers. This simple and flexible technique is called â€Å"imagined time and space† in Chinese operatic terminology. The acting, however, is not mere imitation of movements in daily life. Instead, it has been perfected to bring out just their essentials, making them highly-stylize and rhythmic dancing movements. Such acting is described in Chinese stage language as â€Å"stylized formula†. In addition, Chinese opera has specific costumes, facial make-ups, musical motifs and recitations to represent each character in the series of characters known as Xingtous. All this, plus imagined time and space and stylized acting, has enabled the story to rise above real life and create a strong dramatic atmosphere with distinct operatic effects. The history of Chinese opera dates as far back as the third century, simple plays were performed as part of court entertainment. In the twelfth century, during the Southern Song Dynasty (1271-1368). The Yuan zaju is a landmark in the development of traditional drama. It took social life as its main subject matter and was very popular at that time. Guan Hanqing is considered the greatest Yuan dramatist. One of his plays, The Wrongs Suffered by Dou E, is still appreciated by today’s audiences. In the later years of the Yuan Dynasty, Yuan zaju was gradually replaced by nanxi, a kind of southern opera. By the middle Ming Dynasty, a combination of Yuan zaju and nanxi, known as poetic drama, appeared. The Romance of drama, was written by Tang Xianzu who is considered the â€Å"Chinese Shakespeare During the late Qing Dynasty, a new type of traditional drama-Beijing Opera-came into being. In 1790, some troupes of Auhui Opera went to the Imperial Palace in Beijing to offer birthday congratulations to the emperor and other members of the royal family. They remained in Beijing and performed for the ordinary citizens. Because of their efforts to learn artistic techniques from other local operas and to the taste of the Based on Anhui Opera, Beijing Opera, Beijing Opera took shape as an independent opera form between 1840 and 1860. Having incorporated the merits of many other local dramas, Beijing Opera not only appeals to Chinese audiences but is warmly received by people all over the world. In the course of the development of the development of Chinese traditional opera, mutual borrowing has taken place among various types of local opera and new forms throughout have appeared continually. Recent surveys show there are 368 different forms of opera the country. Each variety takes its name from the place where it originated and is popular. The use of local dialects and unique melodies distinguish the different types of opera. Among the best known forms are Beijing Opera (actually a national form), Pingju (popular in the north), Shaoxing opera (popular in Zhejing Province and Shanghai), Yuju (a kind of Henan Opera), Kunqu (Kunshan Opera, popular mainly in Jiangsu Province), Qinqiang (Shaanxi Opera), Chuanju (Sichuan Opera), Hanju (Hubei Opera), and Yueju (Guangzhou Opera). Features of Chinese Opera and World Music;   A Synthesis:  China is the home of one of the oldest civilizations in the world, and is also home to the earliest musical scale in recorded human history. For ages, Chinese music has been seeking a type of spiritual release, a doorway to vitality. It is like looking for spirituality with a unique dignity of its own. Now, we are starting to see the religious sounds heard from the pious and faithful people throughout Tibet slowly being infused into the beautiful music we hear everyday, bringing us a quiet, serene peace of mind, as it does not strive to be real in its physical presentation, since it is more to instruct than to amuse.

The Roman Empire Essay - 2154 Words

Kevin Paltoo EUH 1000 Mr. Rogers 04/10/2010 The Lex Oppia was a law established in ancient Rome in 215 BC, at the height of the Second Punic War during the days of national catastrophe after the Battle of Cannae. This law was designed to limit the rights of women. The law was also passed to tap into wealthy women fortunes by the state in order to pay for the costs of the war. This law basically stripped the rights of women. Marcus Porcius Cato also known as the censor is one of the statesmen that supported the Lex Oppia law. Marcus Porcius Cato was one of the statesmen who reject repealing the Lex Oppia law. Cato stated â€Å" If each of us, citizens, had determined to assert his rights and dignity as a husband with respect to his own†¦show more content†¦The Romans were more interested in practical matters of law, governance, and military strategy than they were in philosophy and art. But for Cicero to really use philosophy effectively, he needed to make it accessible to a Roman audience. He did this in part by translating Greek works into Latin, including inventing Latin words where none seemed suitable for Greek concepts (including the Latin words which give us the English words morals, property, individual, science, image, and appetite), and in part by drawing on and idealizing Roman history to provide examples of appropriate conduct and to illustrate the arguments of philosophy. He also summarized in Latin many of the beliefs of the primary Greek philosophical schools of the time. Cicero grew up in a time of civil unrest and war. Sulla’s victory in the first of many civil wars led to a new constitutional framework that undermined liberty which was the fundamental value of the Roman Republic. Nonetheless, Sulla’s reforms strengthened the position of the equestrian class, contributing to that class’s growing political power. Cicero undermined his efforts in preserving the Roman constitution as which he felt was being contaminated by optimates. The consequence of this was that Cicero was exile from Rome because of these actions. Tiberius Gracchus was a Roman politician. As a plebeian tribune, his reforms of agrarian legislation caused political turmoil in the Republic.Show MoreRelatedThe Roman And Roman Empire1068 Words   |  5 PagesThe Roman Empire, which was centered in the city of Rome, was the most extensive western civilization of ancient times. With its major advancements and prosperity it is hard to believe that the Roman Empire suddenly collapsed and fell into a time known as the Dark Ages. After a period of struggles for the Roman E mpire, the empire gradually fell. Rome was the most successful civilization of its time. 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